5 SIMPLE TECHNIQUES FOR PALMITOYLETHANOLAMIDE

Central administration of palmitoylethanolamide decreases hyperalgesia in mice by way of inhibition of NF‐κB nuclear signalling in dorsal root ganglia. Eur J PharmacolCosta and colleagues [178] have proposed that PEA was able to reduce mechanical allodynia and thermal hyperalgesia pursuing sciatic nerve constriction in mice, via an motion on rec

2015). These scientific tests, taken together, propose that, although a direct activation of GPR55 or PPAR‐α takes place, PEA can produce its anti‐inflammatory action in the intestine also via indirect activation of CB1 and CB2 receptors, likely on account of the power of this compound to potentiate the motion of endocannabinoids at these rece